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AimsTo evaluate the effectiveness of a new VMAT‐2 inhibitor NBI‐641449 in controlling hyperkinetic movements of Huntington disease (HD) and to investigate its possible therapeutic effects.
MethodsWe applied three different doses of NBI‐641449 (1, 10, 100 mg/kg/day) for 2 weeks in 4‐month‐old YAC128 mice and wild‐type (WT) mice. Rotarod performance and locomotive activities were tested during the...
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