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To investigate the radioprotective effect of adenine on irradiated lymphocytes and discover the possible mechanisms of protection. Lymphocytes were pretreated for 12 h with adenine (0.001–0.1 μmol·L −1 ) and then exposed to 4 Gy radiation. Cell viability was observed by the MTS assay, apoptosis was detected by Annexin V-FITC/PI, DNA ladder, and caspase 3/7 activity. Caspase-9, Bax, and...
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