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Cell‐selective regulation of protein translocation is achieved through the rational design of an endogenous enzyme‐operated spherical nucleic acids platform. The system enables enzyme‐activated capture of proteins of interest and thus regulation of their cytoplasmic‐nuclear shuttling with tumor‐cell specificity, as reported by Mengyuan Li and co‐workers in their Research Article (e202214958).
Precise regulation of protein activity and localization in cancer cells is crucial to dissect the function of the protein‐involved cellular network in tumorigenesis, but there is a lack of suitable methodology. Here we report the design of enzyme‐operated spherical nucleic acids (E‐SNAs) for manipulation of the nucleocytoplasmic translocation of proteins with cancer‐cell selectivity. The E‐SNAs are...
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