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As genome sequence databases grow in size, the accuracy and speed of sequence similarity detection become more important. There is an increasing number of methods being used for detecting sequence similarity. Meanwhile the demands for genome sequence search and alignment services are also increasing. It is a challenge to scale up the computer systems for hosting various methods and serving requests...
Characterizing the cellular phenotype of the mutated long QT syndrome (LQTS) gene is the bridging approach to relating the molecular dysfunction to the electrophysiological abnormalities. In this study, we model the cellular functional characteristics of the delayed rectifier K+ channel, Ikr, responsible for the LQTS subtype 2. The Levenberg-Marquardt algorithm was used to estimate the transition...
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