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Femtosecond laser has been applied to biological research for its advantages of ultra-high temporal and spatial resolutions, such as optical perforation for DNA transfection, ablation of organelle within living cells. The promise shown by femtosecond laser applied to the biological field has led us to propose femtosecond laser for single-cell level research in biotechnology. Femtosecond optical tweezers,...
Genetic defects in the KCNH2 gene are a primary cause of instable cardiac ventricular repolarization. The aim of this work has been to assess the functional implication of the stoichiometric properties of the mutated KCNH2 protein complex. We have developed both homotetrameric and heterotetrameric kinetic models based on the heterologous expression of wild-type KCNH2 and/or C-terminus mutants in HEK293...
Characterizing the cellular phenotype of the mutated long QT syndrome (LQTS) gene is the bridging approach to relating the molecular dysfunction to the electrophysiological abnormalities. In this study, we model the cellular functional characteristics of the delayed rectifier K+ channel, Ikr, responsible for the LQTS subtype 2. The Levenberg-Marquardt algorithm was used to estimate the transition...
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