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Chronic buspirone or ipsapirone (3 mg/kg, twice daily) administration to rats for 10 days decreased the sensitivity of inhibition of single-unit activity of serotonergic dorsal raphe neurons to a challenge by each drug. The ED 50 for buspirone was increased from 0.1 mg/kg to 1.8 mg/kg, and the ED 50 for ipsapirone was increased from 0.7 mg/kg to 1.2 mg/kg. The binding properties...
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