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RfaH, a paralog of the general transcription factor NusG, is recruited to elongating RNA polymerase at specific regulatory sites. The X-ray structure of Escherichia coli RfaH reported here reveals two domains. The N-terminal domain displays high similarity to that of NusG. In contrast, the α-helical coiled-coil C domain, while retaining sequence similarity, is strikingly different from the β barrel...
Streptolydigin (Stl) is a potent inhibitor of bacterial RNA polymerases (RNAPs). The 2.4 Å resolution structure of the Thermus thermophilus RNAP-Stl complex showed that, in full agreement with the available genetic data, the inhibitor binding site is located ∼20 Å away from the RNAP active site and encompasses the bridge helix and the trigger loop, two elements that are considered to be crucial for...
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