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We attempted to prepare a subcutaneous pharmaceutical form of warfarin based on a suspension or poly(ɛ-caprolactone) microparticles to improve patient adherence. The warfarin suspension had a mean particle size of 20.0μm and in vitro release close to 100% in 72h. Microparticle size and encapsulation efficiencies ranged from 54.0 to 80.0μm and 37.0 to 47.0%, respectively. After 72h, warfarin microparticles...
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