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Objective
To determine if early supplemental intra‐articular α2‐macroglobulin (A2M) has a chondroprotective effect in a collagen II‐induced arthritis (CIA) mice model.
Methods
DBA/1 mice were randomized into four groups (n = 15/group): (a) CIA + 1.2 μg of A2M; (b) CIA + 0.8 μg of A2M; (c) CIA + 0.4 μg of A2M; (d) vehicle + phosphate‐buffered saline (PBS). A2M was injected into right ankles and...
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