Search results for: Kazuhiko Sakamoto

Items from 1 to 20 out of 73 results

article

Significance of neoadjuvant therapy for borderline resectable pancreatic cancer: a multicenter retrospective study

Hiroshi Kurahara, Hiroyuki Shinchi, Takao Ohtsuka, Yoshihiro Miyasaka, more

Langenbeck's Archives of Surgery > 2019 > 404 > 2 > 167-174

Purpose Neoadjuvant therapy (NAT) is increasingly used to improve the prognosis of patients with borderline resectable pancreatic cancer (BRPC) albeit with little evidence of its advantage over upfront surgical resection. We analyzed the prognostic impact of NAT on patients with BRPC in a multicenter retrospective study. Methods Medical data of 165 consecutive patients who underwent treatment for...

article

Outcomes of surgery for hepatocellular carcinoma with tumor thrombus in the inferior vena cava or right atrium

Kazuhiko Sakamoto, Hiroaki Nagano

Surgery Today > 2018 > 48 > 9 > 819-824

The prognosis of hepatocellular carcinoma (HCC) patients with tumor thrombus (TT) in the inferior vena cava (IVC) or right atrium (RA) is extremely poor. We reviewed the recent surgical treatments and outcomes of this form of advanced HCC. TT is classified into three types according to its anatomic location relative to the heart: the inferior hepatic type (type I), where the TT is in the IVC below...

article

Low invasiveness of thoracoscopic esophagectomy in the prone position for esophageal cancer: a propensity score-matched comparison of operative approaches between thoracoscopic and open esophagectomy

Shinsuke Kanekiyo, Shigeru Takeda, Masahito Tsutsui, Mitsuo Nishiyama, more

Surgical Endoscopy > 2018 > 32 > 4 > 1945-1953

Background In this study, cytokine levels, outcome, and survival rates after esophagectomy for esophageal cancer were retrospectively investigated in a propensity score-matched comparison of operative approaches between the thoracoscopic esophagectomy (TE) in the prone position and open esophagectomy (OE). Patients and Methods Between 2005 and 2014, TE was performed on a group of 85 patients, which...

article

Surgical treatment for advanced hepatocellular carcinoma with portal vein tumor thrombus

Kazuhiko Sakamoto, Hiroaki Nagano

Hepatology Research > 47 > 10 > 957 - 962

The Barcelona Clinic Liver Cancer staging system recommends a tyrosine kinase inhibitor (sorafenib) as standard therapy in advanced hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT). Sorafenib has been shown to prolong median overall survival (OS) by approximately 3 months in advanced HCC patients with PVTT (8.1 vs. 4.9 months). However, its clinical effectiveness is still...

article

A phase II, multicenter, single-arm study of tri-weekly low-dose nanoparticle albumin-bound paclitaxel chemotherapy for patients with metastatic or recurrent breast cancer

Shigeru Yamamoto, Noriko Maeda, Yukiko Nagashima, Hidefumi Kubo, more

Breast Cancer > 2017 > 24 > 6 > 783-789

Background Nanoparticle albumin-bound (nab)-paclitaxel is a solvent-free formulation of paclitaxel that is bound to albumin and has demonstrated improved progression free survival in previous studies of breast cancer. However, it is difficult to treat Japanese patients with metastatic or recurrent breast cancer with the recommended dose of 260 mg/m² of (nab)-paclitaxel for more than six cycles due...

article

Rapidly progressive interstitial lung disease due to anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis complicated with cervical cancer: Successful treatment with direct hemoperfusion using polymyxin B-immobilized fiber column therapy

Hidenori Ichiyasu, Yasumiko Sakamoto, Chieko Yoshida, Kazuhiko Sakamoto, more

Respiratory Medicine Case Reports > 2017 > 20 > C > 51-54

The anti-melanoma differentiation-associated gene 5 (MDA-5) antibody is a marker of clinically amyopathic dermatomyositis (CADM) and rapidly progressive interstitial lung disease (ILD) with acute respiratory failure. A 35-year-old woman with cervical cancer showed Gottron's papules, severe hypoxemia, and diffuse ground-glass opacities on chest computed tomography. She was diagnosed with rapidly progressive...

article

Development of suture-assistance devices that facilitate pancreaticojejunostomy: Outcomes of early clinical study

Tomio Ueno, Kazuhiko Sakamoto, Michihisa Iida, Nobuaki Suzuki, more

Pancreatology > 2016 > 16 > 4(S) > S37

article

Risk Factors and Managements of Bile Leakage After Hepatectomy

Kazuhiko Sakamoto, Takao Tamesa, Tokumitu Yukio, Yoshihiro Tokuhisa, more

World Journal of Surgery > 2016 > 40 > 1 > 182-189

Background The purpose of this study was to retrospectively determine the risk factors and evaluate the management of bile leakage. Methods Three hundred and thirty-four patients who underwent hepatectomy for Child classification grade A liver disease, without biliary reconstruction and laparoscopic procedures, between 2003 and 2013 were included. Risk factors were identified using multivariate...

article

Perioperative Microbiologic Monitoring of Sputum on Postoperative Day One as a Predictor of Pneumonia After Hepatectomy

Kazuhiko Sakamoto, Takao Tamesa, Yoshihiro Tokuhisa, Satoshi Matsukuma, more

Journal of Gastrointestinal Surgery > 2015 > 19 > 9 > 1662-1667

Background The purpose of this study was to retrospectively evaluate microbial examination of sputum on postoperative day one (POD1) and to determine risk factors for postoperative pneumonia (POP) after hepatectomy. Methods Two hundred ninety-four patients who expectorated sputum on POD1 after hepatectomy between 2003 and 2014 were investigated. Sputum samples were submitted for microbial examination...

article

Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trial

Yoshinari Maeda, Kiyoshi Yoshimura, Hiroto Matsui, Yoshitaro Shindo, more

Cancer Immunology, Immunotherapy > 2015 > 64 > 8 > 1047-1056

Background We previously reported overexpression of heat-shock protein (HSP) 70 in hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) using proteomic profiling and immunohistochemical staining (IHS). This suggested that HSP70 could be a molecular target for treatment of HCC. Methods Twelve patients with HCV-related HCC were enrolled in a phase 1 clinical trial. Dendritic cells (DCs)...

article

Prognostic factors in patients with septic shock in digestive surgery who have undergone direct hemoperfusion with polymyxin B-immobilized fibers: a retrospective observational study

Satoshi Matsukuma, Kazuhiko Sakamoto, Mitsuo Nishiyama, Takao Tamesa, more

Journal of Intensive Care > 2015 > 3 > 1 > 1-9

Background Direct hemoperfusion with polymyxin B-immobilized fiber (PMX-DHP) has been widely used for patients with septic shock around the world, but the prognostic factors have not been fully understood. We conducted a retrospective analysis to determine the prognostic factors in patients with septic shock who underwent PMX-DHP. Methods Twenty-nine patients with septic shock who...

article

Relationship Between Cytokine Gene Polymorphisms and Risk of Postoperative Pneumonia with Esophageal Cancer

Kazuhiko Sakamoto, Masaaki Oka, Shigehumi Yoshino, Shoichi Hazama, more

Journal of Gastrointestinal Surgery > 2014 > 18 > 7 > 1247-1253

Background We retrospectively evaluated the relationship between cytokine gene polymorphisms and development of postoperative pneumonia after esophagectomy. Methods In 120 patients who underwent esophagectomy, serum samples were obtained to measure levels of serum interleukin (IL)-6 and IL-10 at four time points (preoperatively, postoperative day (POD)0, POD1, and POD3). DNA extracted from peripheral...

article

Carbonaceous and ionic components in ultrafine and fine particles at four sampling sites in the vicinity of roadway intersection

Kyung Hwan Kim, Kazuhiko Sekiguchi, Shinji Kudo, Masatoshi Kinoshita, more

Atmospheric Environment > 2013 > 74 > Complete > 83-92

Ultrafine particles (UFPs; Dp < 0.1 μm) and fine particles (FPs; Dp < 2.5 μm) were simultaneously collected for 11 h periods in the daytime and in the nighttime at four sites (S1–S4) around a roadway intersection in an urban area. Sampling was carried out for 14 consecutive days to determine the effect of the intersection on the chemical composition of atmospheric UFPs and FPs. The relative...

article

Selective H₂ and CO production with rhenium(I) biscarbonyl complexes as photocatalyst

Tatsuki Morimoto, Junji Tanabe, Kazuhiko Sakamoto, Kazuhide Koike, more

Research on Chemical Intermediates > 2013 > 39 > 1 > 437-447

Rhenium(I) biscarbonyl complexes with two phosphine ligands photocatalyzed not only CO₂ reduction under CO₂ atmosphere but also H₂ evolution under Ar. The reductant 1-benzyl-1,4-dihydronicotinamide (BNAH) worked only as a one-electron donor, and it was quantitatively converted to its corresponding oxidized dimer (BNA₂). The photocatalytic reactions required addition of a base such as triethanolamine,...

article

Differences of chemical species and their ratios between fine and ultrafine particles in the roadside environment

Shinji Kudo, Kazuhiko Sekiguchi, Kyung Hwan Kim, Masatoshi Kinoshita, more

Atmospheric Environment > 2012 > 62 > Complete > 172-179

Chemical components of fine particles (FPs; aerodynamic diameter, Dp < 2.5 μm) and ultrafine particles (UFPs; Dp < 0.1 μm) at Japanese and German roadsides were investigated during summer. The UFPs/FPs ratio for organic carbon (OC) concentrations on weekdays was 34.5% and 25.0% at Japanese and German roadsides, respectively, whereas 3.3% and 6.4% for elemental carbon (EC) concentrations, respectively...

article

Carbonaceous aerosol and its characteristics observed in Tokyo and south Kanto region

Hiroaki Minoura, Tazuko Morikawa, Akira Mizohata, Kazuhiko Sakamoto

Atmospheric Environment > 2012 > 61 > Complete > 605-613

Due to enforcing vehicle emission reduction requirements in Japan, particulate matter (PM) concentration, especially elemental carbon (EC) concentration in roadside atmosphere, obviously decreased in the last decade. In spite of the previous vehicle emission reduction, EC concentration was not shown a clear decrease, recently. To achieve the PM2.5 environmental standard, measurements based on emission...

article

Gas/particle partitioning of low-molecular-weight dicarboxylic acids at a suburban site in Saitama, Japan

Linfa Bao, Mariko Matsumoto, Tsutomu Kubota, Kazuhiko Sekiguchi, more

Atmospheric Environment > 2012 > 47 > Complete > 546-553

Low-molecular-weight dicarboxylic acids (diacids) exhibit semivolatile behavior in the atmosphere, but their partitioning between the gaseous and particulate phases is still unclear. An annular denuder–filter pack system with a cyclone PM _2.5 was employed to investigate the gaseous and particulate phase concentrations of diacids, with high collection efficiency of most target compounds. Saturated...

article

Spatial distributions of ultrafine particles and their behavior and chemical composition in relation to roadside sources

Shinji Kudo, Kazuhiko Sekiguchi, Kyung Hwan Kim, Kazuhiko Sakamoto

Atmospheric Environment > 2011 > 45 > 35 > 6403-6413

Vertical and horizontal distributions of the chemical components of ultrafine particles (UFP; <0.1μm) in relation to roadside sources were investigated by using a newly developed PM _0.1 collection system with a UFP impactor filter (50% cut-off, 0.1μm; air flow rate, 40.0Lmin ⁻¹ ). UFP were measured at a suburban roadside, at two background sites in Saitama (summer 2007 and winter...

article

Daytime meteorological structures causing elevated photochemical oxidants concentrations in north Kanto, Japan

Shinri Hosoi, Hiroshi Yoshikado, Kazuhiko Sekiguchi, Qingyue Wang, more

Atmospheric Environment > 2011 > 45 > 26 > 4421-4428

The north Kanto area is about 150 km north of the heavily populated and industrialized Tokyo metropolis, and local emissions of photochemical oxidants (Ox) precursors are limited because of little anthropogenic emission. Nevertheless, high Ox concentrations exceeding the warning level for Ox (>120 ppbv, 1-h average) are often observed there. We recently reported that high Ox concentrations in the...

article

Seasonal variation of carbonaceous and ionic components in ultrafine and fine particles in an urban area of Japan

Kyung Hwan Kim, Kazuhiko Sekiguchi, Masami Furuuchi, Kazuhiko Sakamoto

Atmospheric Environment > 2011 > 45 > 8 > 1581-1590

The carbonaceous and ionic components of atmospheric ultrafine particles (UFPs; Dp<0.1μm) and fine particles (FPs; Dp<2.5μm) were measured four times during one year in Saitama City, Japan, in order to observe the seasonal variation of chemical components, to characterize the chemical components for the two particle sizes, and to estimate the possible emission sources qualitatively. Generally,...

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Search results for: Kazuhiko Sakamoto

Significance of neoadjuvant therapy for borderline resectable pancreatic cancer: a multicenter retrospective study

Outcomes of surgery for hepatocellular carcinoma with tumor thrombus in the inferior vena cava or right atrium

Low invasiveness of thoracoscopic esophagectomy in the prone position for esophageal cancer: a propensity score-matched comparison of operative approaches between thoracoscopic and open esophagectomy

Surgical treatment for advanced hepatocellular carcinoma with portal vein tumor thrombus

A phase II, multicenter, single-arm study of tri-weekly low-dose nanoparticle albumin-bound paclitaxel chemotherapy for patients with metastatic or recurrent breast cancer

Rapidly progressive interstitial lung disease due to anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis complicated with cervical cancer: Successful treatment with direct hemoperfusion using polymyxin B-immobilized fiber column therapy

Development of suture-assistance devices that facilitate pancreaticojejunostomy: Outcomes of early clinical study

Risk Factors and Managements of Bile Leakage After Hepatectomy

Perioperative Microbiologic Monitoring of Sputum on Postoperative Day One as a Predictor of Pneumonia After Hepatectomy

Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trial

Prognostic factors in patients with septic shock in digestive surgery who have undergone direct hemoperfusion with polymyxin B-immobilized fibers: a retrospective observational study

Relationship Between Cytokine Gene Polymorphisms and Risk of Postoperative Pneumonia with Esophageal Cancer

Carbonaceous and ionic components in ultrafine and fine particles at four sampling sites in the vicinity of roadway intersection

Selective H₂ and CO production with rhenium(I) biscarbonyl complexes as photocatalyst

Differences of chemical species and their ratios between fine and ultrafine particles in the roadside environment

Carbonaceous aerosol and its characteristics observed in Tokyo and south Kanto region

Gas/particle partitioning of low-molecular-weight dicarboxylic acids at a suburban site in Saitama, Japan

Spatial distributions of ultrafine particles and their behavior and chemical composition in relation to roadside sources

Daytime meteorological structures causing elevated photochemical oxidants concentrations in north Kanto, Japan

Seasonal variation of carbonaceous and ionic components in ultrafine and fine particles in an urban area of Japan

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