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To investigate the impact of prostatic apical shape from preoperative magnetic resonance imaging on early recovery of urinary continence after robot-assisted radical prostatectomy (RARP).We reviewed the records of 1011 patients who underwent RARP at a tertiary center from October 2007 to March 2013. Patients were stratified into 4 different groups by prostatic apical shapes as shown on preoperative...
To investigate potential predictors of biochemical recurrence (BCR) in patients with localized prostate cancer with negative surgical resection margin (SRM).Data from 582 consecutive patients diagnosed with localized prostate cancer with negative SRM who underwent only radical prostatectomy between November 2003 and April 2010 were reviewed. Pathologic prostate-specific antigen (PSA) mass ratio was...
To evaluate conventional magnetic resonance imaging (MRI), prostate needle biopsy (PBx), and the combination of both tests in predicting the laterality of final specimen pathology after radical prostatectomy. A total of 574 radical prostatectomy cases that had PBx with at least 12 cores and preoperative prostate MRI with pelvic coil were included. We analyzed the clinicopathologic data with laterality...
Tight junctions are important for uroepithelial paracellular permeability barriers. In the present study, we examined the developmental changes in the expression of coxsackievirus and adenovirus receptor (CAR) isoforms in mouse bladder uroepithelium.Multiplex reverse transcriptase polymerase chain reaction using CAR isoform-specific primer sets and Western blotting were conducted on gestational day...
To investigate the potential effect of body mass index (BMI) on prostate cancer detection among Korean men who underwent prostate biopsy via contemporary multi (≥12)-core approach.We reviewed records of 3113 Korean men who underwent initial multi (≥12)-core prostate biopsy at our institution. Variables including age, prostate-specific antigen (PSA), digital rectal exam (DRE) finding, prostate volume,...
To investigate the prognostic significance of undetectable ultrasensitive prostate-specific antigen (PSA) nadir in patients who received radical prostatectomy (RP) for prostate cancer.We reviewed records of 384 patients who received RP for prostate cancer and were followed for at least 2 years with ultrasensitive PSA testing. Undetectable ultrasensitive PSA level was defined as <0.001 ng/mL. Subjects...
To assess the prognostic value of the width of a healthy surgical margin in the enucleoresection of small renal cell carcinoma, in which 68% of cases had a margin width of 3.0 mm or less.We retrospectively reviewed 98 consecutive enucleoresections regarding the width of healthy margin and tumor recurrence in 96 patients followed up for more than 3 years after surgery. The mean follow-up was 70.8 months...
To investigate the prognostic value of Ki-67, cyclooxygenase-2 (COX-2), E-cadherin, and retinoblastoma protein (pRB) in patients with urothelial carcinoma of the upper urinary tract.From January 1998 to December 2005, the specimens from 107 patients with urothelial carcinoma of the upper urinary tract who had undergone nephroureterectomy were analyzed. The expression of Ki-67, COX-2, E-cadherin, and...
To investigate the incidence and predictive factors associated with newly developed chronic kidney disease (CKD) after curative surgery in patients with small renal tumors.From 1998 to 2005, we retrospectively investigated 225 patients undergoing partial nephrectomy (PN) or radical nephrectomy (RN) for renal tumors, of size ≤ 4 cm, with normal contralateral kidney. The glomerular filtration rate (GFR)...
To examine the change in prostate-specific antigen (PSA) levels and prostate volume (PV) in octogenarian men compared with those in septuagenarian men and evaluate the possibility of PSA as a surrogate marker for PV in octogenarian men.A total of 441 men were recruited from whom random and selected oldest-old samples (age ≥85 years) from the Korean Longitudinal Study on Health and Aging, which was...
To investigate the distributive pattern of nerves surrounding the prostate by analyzing specimens from non–nerve-sparing radical retropubic prostatectomy (RRP).We histologically analyzed specimens from 95 cases of non–nerve-sparing RRPs performed at our institution by examining 12 representative slides from each case. We reconstructed images from scanning the slides and prepared them for analysis...
Evidence has shown that a relationship exists between lower urinary tract symptoms and the metabolic syndrome. We investigated the relationship between the metabolic syndrome and lower urinary tract symptoms in a community-based elderly population.We collected data from the Korean Longitudinal Study on Health and Aging. We selected a total of 348 male participants by random sampling. The selected...
To investigate the relationship between prostate-specific antigen (PSA) and prostate volume in a histologically defined subset of Korean men confirmed to have benign prostatic hyperplasia (BPH) only from multicore biopsy of prostate.A total of 707 Korean men with a PSA level of 10 ng/mL or lower who were shown to have stromoglandular hyperplasia only from transrectal ultrasound (TRUS)-guided multicore...
To investigate the association of prostate size with aggressiveness of prostate cancer in Korean men who received radical retropubic prostatectomy (RRP) for clinically localized prostate cancer.We evaluated the association of RRP specimen weight and prostate volume measured by transrectal ultrasound (TRUS) with pathologic tumor grade, extraprostatic extension of disease, surgical margin status, and...
To compare different biopsy schemes for detecting prostate cancer in Korean men.A total of 516 men, 40 to 79 years old (mean 64.1 ± 7.8), constituted the study cohort. The patients were divided to quartiles according to prostate volume: 10 to 30, 30.1 to 40, 40.1 to 55, and 55.1 to 162 cm 3 .The cancer detection rates decreased as the prostate volume increased in the quartiles used (P = 0...
To investigate the impact of variations in bony pelvic dimensions observed from preoperative magnetic resonance imaging on operative time, intraoperative blood loss, and surgical margin status on performing open radical retropubic prostatectomy.A prospective study was undertaken in which preoperative magnetic resonance imaging was performed in 190 patients who were diagnosed with clinically localized...
To investigate the significance of variations in neurovascular bundle (NVB) formation observed on preoperative magnetic resonance imaging (MRI) regarding postoperative potency after nerve-sparing radical retropubic prostatectomy (RRP).Preoperative MRI was performed in 93 patients who underwent bilateral nerve-sparing RRP for clinically localized prostate cancer and were followed up for at least 12...
To investigate the expression of survivin in renal cell carcinoma and try to define its association with certain pathologic features and the clinical outcome.The tissue samples from 85 consecutive renal cell carcinoma specimens were obtained from patients who had undergone radical or partial nephrectomy. The mean follow-up was 45 months (range 3 to 60). Immunohistochemical staining of the paraffin...
To investigate the clinical and pathologic characteristics of prostate cancer in Korean men to determine how ethnic differences affect clinical outcome.The clinical and pathologic data of 604 Korean men who underwent radical prostatectomy from 1994 to 2003 were reviewed. Biochemical failure was defined as a prostate-specific antigen (PSA) level of 0.2 ng/mL or greater on two consecutive occasions...
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