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Die amyotrophe Lateralsklerose (ALS) ist eine rasch progrediente Degeneration sowohl des ersten als auch des zweiten motorischen Neurons. Klinische Charakteristika sind fortschreitende, sich kontinuierlich über den Körper ausbreitende Paresen und Atrophien der Extremitätenmuskulatur. Die Genetik der ALS ist in den letzten 5 Jahren komplexer geworden. Neben den häufigen SOD1-Mutationen kamen die seltener...
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