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Integrins are heterodimeric transmembrane proteins, which mediate cell–cell and cell–extracellular matrix (ECM) interaction. We show, that an inhibitor of alpha5 beta1 integrin (α5β1), JSM6427, attenuated glioma growth and decreased the density of microglia at the tumor border. 21 days after glioma cell injection into an experimental mouse model, the tumor volume was significantly smaller after treating...
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