Search results for: Jan Fahrenkrug

Items from 1 to 20 out of 61 results

article

Spatiotemporal expression pattern of PERIOD 1 and PERIOD 2 in the mouse SCN is dependent on VIP receptor 2 signaling

Jens Hannibal, Tania H. B. Norn, Birgitte Georg, Jan Fahrenkrug

European Journal of Neuroscience > 50 > 7 > 3115 - 3132

Neurons of the hypothalamic suprachiasmatic nucleus (SCN) express clock genes, which regulate their own transcription and generate daily output signals driving circadian rhythmic behavior and physiology. The neuropeptide VIP and its specific receptor, the VPAC2 receptor, are important for synchronization of clock neurons. In the present study, we characterized PER1 and PER2 expressing neurons in wild‐type...

article

PACAP in hypothalamic regulation of sleep and circadian rhythm: importance for headache

Philip R. Holland, Mads Barloese, Jan Fahrenkrug

The Journal of Headache and Pain > 2018 > 19 > 1 > 1-8

The interaction between sleep and primary headaches has gained considerable interest due to their strong, bidirectional, clinical relationship. Several primary headaches demonstrate either a circadian/circannual rhythmicity in attack onset or are directly associated with sleep itself. Migraine and cluster headache both show distinct attack patterns and while the underlying mechanisms of this circadian...

article

Mice Lacking EGR1 Have Impaired Clock Gene (BMAL1) Oscillation, Locomotor Activity, and Body Temperature

Casper Schwartz Riedel, Birgitte Georg, Henrik L. Jørgensen, Jens Hannibal, more

Journal of Molecular Neuroscience > 2018 > 64 > 1 > 9-19

Early growth response transcription factor 1 (EGR1) is expressed in the suprachiasmatic nucleus (SCN) after light stimulation. We used EGR1-deficient mice to address the role of EGR1 in the clock function and light-induced resetting of the clock. The diurnal rhythms of expression of the clock genes BMAL1 and PER1 in the SCN were evaluated by semi-quantitative in situ hybridization. We found no difference...

article

Melanopsin expressing human retinal ganglion cells: Subtypes, distribution, and intraretinal connectivity

Jens Hannibal, Anders Tolstrup Christiansen, Steffen Heegaard, Jan Fahrenkrug, more

Journal of Comparative Neurology > 525 > 8 > 1934 - 1961

Intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin belong to a heterogenic population of RGCs which regulate the circadian clock, masking behavior, melatonin suppression, the pupillary light reflex, and sleep/wake cycles. The different functions seem to be associated to different subtypes of melanopsin cells. In rodents, subtype classification has associated...

article

Hair dyeing, hair washing and hair cortisol concentrations among women from the healthy start study

Sheila K. Kristensen, Sofus C. Larsen, Nanna J. Olsen, Jan Fahrenkrug, more

Psychoneuroendocrinology > 2017 > 77 > C > 182-185

Hair cortisol concentration (HCC) has been suggested as a promising marker for chronic stress. However, studies investigating the influence of hair dyeing and hair washing frequency on HCC have shown inconsistent results.To examine associations between HCC and hair dyeing status or weekly hair washing frequency among women.This cross-sectional study was based on data from 266 mothers participating...

article

PKA, novel PKC isoforms, and ERK is mediating PACAP auto-regulation via PAC1R in human neuroblastoma NB-1 cells

Birgitte Georg, Birgitte Falktoft, Jan Fahrenkrug

Neuropeptides > 2016 > 60 > C > 83-89

The neuropeptide PACAP is expressed throughout the central and peripheral nervous system where it modulates diverse physiological functions including neuropeptide gene expression. We here report that in human neuroblastoma NB-1 cells PACAP transiently induces its own expression. Maximal PACAP mRNA expression was found after stimulation with PACAP for 3h. PACAP auto-regulation was found to be mediated...

article

Period1 gates the circadian modulation of memory‐relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK

Oliver Rawashdeh, Antje Jilg, Erik Maronde, Jan Fahrenkrug, more

Journal of Neurochemistry > 138 > 5 > 731 - 745

Memory performance varies over a 24‐h day/night cycle. While the detailed underlying mechanisms are yet unknown, recent evidence suggests that in the mouse hippocampus, rhythmic phosphorylation of mitogen‐activated protein kinase (MAPK) and cyclic adenosine monophosphate response element‐binding protein (CREB) are central to the circadian (~ 24 h) regulation of learning and memory. We recently identified...

chapter

VIP and PACAP

Jan Fahrenkrug

Results and Problems in Cell Differentiation > Cellular Peptide Hormone Synthesis and Secretory Pathways > 1-20

Vasoactive intestinal polypeptide (VIP) is derived from a 170 amino acid precursor which in addition is processed to preproVIP 22-79, PHI, preproVIP 111-122 and preproVIP 156-170. All preproVIP-derived peptides have been shown in normal tissue and VIP-producing cell lines and elevated quantities occur in plasma and tumour tissues from patients with VIP-producing tumours. In some tissues the dibasic...

article

The Light‐Induced FOS Response in Melanopsin Expressing HEK‐293 Cells is Correlated with Melanopsin Quantity and Dependent on Light Duration and Irradiance

Birgitte Georg, Lene Rask, Jens Hannibal, Jan Fahrenkrug

Photochemistry and Photobiology > 90 > 5 > 1069 - 1076

We established a cell line (HEK‐hMel) expressing melanopsin in a tetracycline dependent manner to elucidate new aspects of melanopsin's light response. Different light stimuli were evaluated using FOS expression as response parameter. Immunoblotting was used to evaluate expression of melanopsin and FOS and qPCR to quantify FOS mRNA responses. The magnitude of the FOS response was found to correlate...

article

Diurnal variation of von Willebrand factor in plasma: the Bispebjerg study of diurnal variations

Annette Timm, Jan Fahrenkrug, Henrik L. Jørgensen, Henriette P. Sennels, more

European Journal of Haematology > 93 > 1 > 48 - 53

BackgroundQuantitation of von Willebrand factor (VWF) in plasma is a central element in assessing von Willebrand disease (VWD). VWF activity is known to vary, which has partly been ascribed to biological and preanalytical variation. However, a possible diurnal expression of VWF has not been thoroughly tested. ObjectivesWe examined whether VWF antigen and VWF activity in plasma display a diurnal profile...

article

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) in the circulation after sumatriptan

Jakob Møller Hansen, Jan Fahrenkrug, Jesper Petersen, Troels Wienecke, more

Scandinavian Journal of Pain > 2013 > 4 > 4 > 211-216

The origin of migraine pain is still elusive, but increasingly researchers focus on the neuropeptides in the perivascular space of cranial vessels as important mediators of nociceptive input during migraine attacks. The parasympathetic neurotransmitters, pituitary adenylate cyclase activating peptide-38 (PACAP38) and vasoactive intestinal peptide (VIP) may be released from parasympathetic fibres and...

article

Circadian clock components in the rat neocortex: daily dynamics, localization and regulation

Martin F. Rath, Kristian Rohde, Jan Fahrenkrug, Morten Møller

Brain Structure and Function > 2013 > 218 > 2 > 551-562

The circadian master clock of the mammalian brain resides in the suprachiasmatic nucleus (SCN) of the hypothalamus. At the molecular level, the clock of the SCN is driven by a transcriptional/posttranslational autoregulatory network with clock gene products as core elements. Recent investigations have shown the presence of peripheral clocks in extra-hypothalamic areas of the central nervous system...

article

Differential expression of melanopsin mRNA and protein in Brown Norwegian rats

Jens Hannibal, Birgitte Georg, Jan Fahrenkrug

Experimental Eye Research > 2013 > 106 > Complete > 55-63

Melanopsin is expressed in a subpopulation of retinal ganglion cells rendering these cells intrinsically photosensitive (ipRGCs). The ipRGCs are the primary RGCs mediating light entrainment of the circadian clock and control of the pupillary light reflex, light regulated melatonin secretion and negative masking behaviour. Previous studies have demonstrated that melanopsin expression in albino rats...

article

Circadian rhythms and food anticipatory behavior in Wfs1-deficient mice

Hendrik Luuk, Jan Fahrenkrug, Jens Hannibal

Biochemical and Biophysical Research Communications > 2012 > 424 > 4 > 717-723

The dorsomedial hypothalamic nucleus (DMH) has been proposed as a candidate for the neural substrate of a food-entrainable oscillator. The existence of a food-entrainable oscillator in the mammalian nervous system was inferred previously from restricted feeding-induced behavioral rhythmicity in rodents with suprachiasmatic nucleus lesions. In the present study, we have characterized the circadian...

article

Altered pupillary light reflex in PACAP receptor 1-deficient mice

Anna Engelund, Jan Fahrenkrug, Adrian Harrison, Hendrik Luuk, more

Brain Research > 2012 > 1453 > Complete > 17-25

The pupillary light reflex (PLR) is regulated by the classical photoreceptors, rods and cones, and by intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin. IpRGCs receive input from rods and cones and project to the olivary pretectal nucleus (OPN), which is the primary visual center involved in PLR. Mice lacking either the classical photoreceptors or...

article

Altered Rhythm of Adrenal Clock Genes, StAR and Serum Corticosterone in VIP Receptor 2-Deficient Mice

Jan Fahrenkrug, Birgitte Georg, Jens Hannibal, Henrik Løvendahl Jørgensen

Journal of Molecular Neuroscience > 2012 > 48 > 3 > 584-596

The circadian time-keeping system consists of clocks in the suprachiasmatic nucleus (SCN) and in peripheral organs including an adrenal clock linked to the rhythmic corticosteroid production by regulating steroidogenic acute regulatory protein (StAR). Clock cells contain an autonomous molecular oscillator based on a group of clock genes and their protein products. Mice lacking the VPAC2 receptor display...

article

Expression of the clock genes Per1 and Bmal1 during follicle development in the rat ovary. Effects of gonadotropin stimulation and hypophysectomy

Søren Gräs, Birgitte Georg, Henrik L. Jørgensen, Jan Fahrenkrug

Cell and Tissue Research > 2012 > 350 > 3 > 539-548

Daily oscillations of clock genes have recently been demonstrated in the ovaries of several species. Clock gene knockout or mutant mice demonstrate a variety of reproductive defects. Accumulating evidence suggests that these rhythms act to synchronise the expression of specific ovarian genes to hypothalamo-pituitary signals and that they are regulated by one or both of the gonadotropins. The aim of...

article

Molecular fingerprint of neuropeptide s‐producing neurons in the mouse brain

Xiaobin Liu, Joanne Zeng, Anni Zhou, Elvar Theodorsson, more

Journal of Comparative Neurology > 519 > 10 > 1847 - 1866

Neuropeptide S (NPS) has been associated with a number of complex brain functions, including anxiety‐like behaviors, arousal, sleep‐wakefulness regulation, drug‐seeking behaviors, and learning and memory. In order to better understand how NPS influences these functions in a neuronal network context, it is critical to identify transmitter systems that control NPS release and transmitters that are co‐released...

article

Localisation of the neuropeptide PACAP and its receptors in the rat parathyroid and thyroid glands

Jan Fahrenkrug, Jens Hannibal

General and Comparative Endocrinology > 2011 > 171 > 1 > 105-113

PACAP (pituitary adenylate cyclase activating polypeptide) is widely distributed neuropeptide acting via three subtypes of receptors, PAC ₁ , VPAC ₁ and VPAC ₂ . Here we examined the localisation and nature of PACAP-immunoreactive nerves in the rat thyroid and parathyroid glands and defined the distribution of PAC ₁ , VPAC ₁ and VPAC ₂ receptor mRNA’s...

article

Cholecystokinin (CCK)‐expressing neurons in the suprachiasmatic nucleus: innervation, light responsiveness and entrainment in CCK‐deficient mice

Jens Hannibal, Christian Hundahl, Jan Fahrenkrug, Jens F. Rehfeld, more

European Journal of Neuroscience > 32 > 6 > 1006 - 1017

The suprachiasmatic nucleus (SCN) is the principal pacemaker driving circadian rhythms of physiology and behaviour. Neurons within the SCN express both classical and neuropeptide transmitters which regulate clock functions. Cholecyctokinin (CCK) is a potent neurotransmitter expressed in neurons of the mammalian SCN, but its role in circadian timing is not known. In the present study, CCK was demonstrated...

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Search results for: Jan Fahrenkrug

Spatiotemporal expression pattern of PERIOD 1 and PERIOD 2 in the mouse SCN is dependent on VIP receptor 2 signaling

PACAP in hypothalamic regulation of sleep and circadian rhythm: importance for headache

Mice Lacking EGR1 Have Impaired Clock Gene (BMAL1) Oscillation, Locomotor Activity, and Body Temperature

Melanopsin expressing human retinal ganglion cells: Subtypes, distribution, and intraretinal connectivity

Hair dyeing, hair washing and hair cortisol concentrations among women from the healthy start study

PKA, novel PKC isoforms, and ERK is mediating PACAP auto-regulation via PAC1R in human neuroblastoma NB-1 cells

Period1 gates the circadian modulation of memory‐relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK

VIP and PACAP

The Light‐Induced FOS Response in Melanopsin Expressing HEK‐293 Cells is Correlated with Melanopsin Quantity and Dependent on Light Duration and Irradiance

Diurnal variation of von Willebrand factor in plasma: the Bispebjerg study of diurnal variations

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) in the circulation after sumatriptan

Circadian clock components in the rat neocortex: daily dynamics, localization and regulation

Differential expression of melanopsin mRNA and protein in Brown Norwegian rats

Circadian rhythms and food anticipatory behavior in Wfs1-deficient mice

Altered pupillary light reflex in PACAP receptor 1-deficient mice

Altered Rhythm of Adrenal Clock Genes, StAR and Serum Corticosterone in VIP Receptor 2-Deficient Mice

Expression of the clock genes Per1 and Bmal1 during follicle development in the rat ovary. Effects of gonadotropin stimulation and hypophysectomy

Molecular fingerprint of neuropeptide s‐producing neurons in the mouse brain

Localisation of the neuropeptide PACAP and its receptors in the rat parathyroid and thyroid glands

Cholecystokinin (CCK)‐expressing neurons in the suprachiasmatic nucleus: innervation, light responsiveness and entrainment in CCK‐deficient mice

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