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That leukocytes can produce proteins with cell-killing activities has been known for almost 30 years (Granger GA, Kolb EP. J. Immunol 1968, 101; Ruddle NH, Waksman BH. J Exp Med 1968, 128, 1267-1279; Carswell EA, Old LJ, Kassel S, Green S, Fiore N, Williamson B. Proc Natl Acad Sci USA 1975, 72, 3666-3670). However, it is only recently that the nature of this cell killing activity has become clear...
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