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Inhibition of apoptotic response of host cells during an early phase of infection is a strategy used by many enteroinvasive bacterial pathogens to enhance their survival. Here, we report the identification of a soluble form of the pilus protein FimA from the culture supernatants of E. coli K1, Salmonella, and Shigella that can potently inhibit Bax-mediated release of cytochrome c from isolated mitochondria...
Although mRNAs of multiple isoforms of Bax, which encodes a central regulator of apoptosis signaling, have been reported, only Baxα protein has been well documented and studied. Baxα exists in latent form and is activated upon apoptosis induction through conformational changes. Here we demonstrate that Baxβ protein is ubiquitously present among human cells, but its activity is restricted through stringent...
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