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BackgroundA KCNE1 polymorphism, D85N, causes long QT syndrome (LQTS) with a decrease in the slowly activating delayed‐rectifier K+ channel current (IKs). We examined impacts of D85N polymorphism on KCNE1 protein stability and functions, and tested the ability of various drugs to modify them.
MethodsKCNE1‐D85N or the wild‐type protein was coexpressed in COS7 cells with KCNQ1 to form K+ channels. Expression,...
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