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Chemotherapeutics can induce immunogenic cell death (ICD) by triggering autophagy and mediate antitumor immunotherapy. However, using chemotherapeutics alone can only cause mild cell‐protective autophagy and be incapable of inducing sufficient ICD efficacy. The participation of autophagy inducer is competent to enhance autophagy, so the level of ICD is promoted and the effect of antitumor immunotherapy...
Enhanced Tumor Immunotherapies
Tailor‐made polymeric nanoparticles with the function of autophagy cascade amplification due to the co‐delivery of autophagy inducer STF‐62247 and antitumor drug epirubicin, which could assist cell uptake and tumor penetration with the help of arginine and promote immunogenic cell death by the enhancement of autophagy for the best tumor immunotherapy effect. More details...
Tumor cells are dominant in the nutritional competition in the tumor microenvironment, and their metabolic abnormalities often lead to microenvironmental acidosis and nutrient deprivation, thereby impairing the function of immune cells and diminishing the antitumor therapeutic effect. Herein, a branched polymeric conjugate and its efficacy in attenuating the metabolic competition of tumor cells are...
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