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Lung cancer is the second most prevalent cancer and the leading cause of cancer‐related death worldwide. Surgery, chemotherapy, molecular targeted therapy, immunotherapy, and radiotherapy are currently available as treatment methods. However, drug resistance is a significant factor in the failure of lung cancer treatments. Novel therapeutics have been exploited to address complicated resistance mechanisms...
Yes‐associated protein (YAP) has been identified as a key driver for epidermal growth factor receptor‐tyrosine kinase inhibitor (EGFR‐TKI) resistance. Inhibition of YAP expression could be a potential therapeutic option for treating non‐small‐cell lung cancer (NSCLC). Herein, a nanococktail therapeutic strategy is proposed by employing amphiphilic and block‐dendritic‐polymer‐based nanoparticles (NPs)...
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