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Background: Sulfatase 2 (SULF2), an extracellular heparan sulphate 6‐O‐endosulphatase, has an oncogenic effect in hepatocellular carcinoma (HCC) that is partially mediated through glypican 3, which promotes heparin‐binding growth factor signalling and HCC cell growth. SULF2 also increases phosphorylation of the anti‐apoptotic Akt kinase substrate GSK3β and SULF2 expression is associated with a decreased...
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