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To study the molecular mechanism of neuronal cell death, we carried out the screening of genes which were induced during the neuronal cell death of neuronal PC12. We cloned the cDNA of rat GADD45γ, the third member of the GADD45 family. Induction of GADD45γ mRNA was observed in the neuronal cell death caused by depletion of neurotrophic factor and Ca 2+ ionophore treatment. Overexpression...
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