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Background
Most patients with juvenile myelomonocytic leukemia (JMML) are curable only with allogeneic hematopoietic cell transplantation (HCT). However, the current standard conditioning regimen, busulfan‐cyclophosphamide‐melphalan (Bu‐Cy‐Mel), may be associated with higher risks of morbidity and mortality. ASCT1221 was designed to test whether the potentially less‐toxic myeloablative conditioning...
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