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Background Epigenetic regulation of chromatin states is thought to control the self-renewal and differentiation of embryonic stem (ES) cells. However, the roles of repressive histone modifications such as trimethylated histone 4 lysine 20 (H4K20me3) in pluripotency and development are largely unknown. Results Here, we show that the histone lysine methyltransferase SMYD5 mediates H4K20me3 at heterochromatin...
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