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In an established rat model of penetrating ballistic‐like brain injury (PBBI), arylsulfatase B (ARSB; N‐acetylgalactosamine 4‐sulfatase) activity was significantly reduced at the ipsilateral site of injury, but unaffected at the contralateral site or in sham controls. In addition, the ARSB substrate chondroitin 4‐sulfate (C4S) and total sulfated glycosaminoglycans increased. The mRNA expression of...
In utero ethanol exposure causes fetal alcohol spectrum disorders, associated with reduced brain plasticity; the mechanisms of these effects are not well understood, particularly with respect to glial involvement. Astrocytes release factors that modulate neurite outgrowth. We explored the hypothesis that ethanol inhibits neurite outgrowth by increasing the levels of inhibitory chondroitin sulfate...
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