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The SmD183–119 peptide is a main target of autoantibodies and T cells in human and murine lupus, but its role in autoimmunity induction remains elusive. Therefore, female Balb/c mice and (NZW × Balb/c)F1 [CWF1] mice with identical MHC haplotype as lupus prone NZB/W mice were immunized with SmD183−119. Immunizations of CWF1 mice with SmD183–119, but not with the controls (irrelevant peptide, HEL peptide,...
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