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Anorexia nervosa (AN) is a mental illness with the highest rates of mortality and relapse, and no approved pharmacological treatment. Using an animal model of AN, called activity‐based anorexia (ABA), we showed earlier that a single intraperitoneal injection of ketamine at a dose of 30 mg/kg (30mgKET), but not 3 mg/kg (3mgKET), has a long‐lasting effect upon adolescent females of ameliorating anorexia‐like...
Objective
This study tested the effects of ketamine on vulnerability of female adolescent mice to activity‐based anorexia (ABA).
Method
Twenty‐four female C57Bl/6 J mice underwent ABA induction, which involved exposing wheel‐acclimated adolescent mice to two bouts of food restriction (FR)—the first ABA (P41–44, mid‐adolescence) and the second ABA (P55–59, late adolescence), with recovery in between...
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