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pH‐dependent peptide biomaterials hold tremendous potential for cell delivery and tissue engineering. However, identification of responsive self‐assembling sequences with specified secondary structure remains a challenge. In this work, An experimental procedure based on the one‐bead one‐compound (OBOC) combinatorial library is developed to rapidly screen self‐assembling β‐sheet peptides at neutral...
Anti‐PD‐L1 monoclonal antibody has achieved substantial success in tumor immunotherapy by T‐cells activation. However, the excessive accumulation of extracellular matrix components induced by unsatisfactory T‐cells infiltration and poor tumor penetration of antibodies make it challenging to realize efficient tumor immunotherapy. Herein, a peptide‐based bispecific nanoblocker (BNB) strategy is reported...
Missed or residual tumor burden results in high risk for bladder cancer relapse. However, existing fluorescent probes cannot meet the clinical needs because of inevitable photobleaching properties. Performance can be improved by maintaining intensive and sustained fluorescence signals via resistance to intraoperative saline flushing and intrinsic fluorescent decay, providing surgeons with sufficiently...