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Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by intense pruritus and eczematous lesion. In this study, topically applied substance P (SP) significantly alleviated AD‐like clinical symptoms in 2, 4, 6‐trinitrochlorobenzene (TNCB)‐induced dermatitis in NC/Nga mice. This effect was nullified by pretreatment of the neurokinin‐1 receptor (NK‐1R) antagonist CP99994. SP treatment...
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