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The cytokine MIF is involved in inflammation and cell proliferation via pathways initiated by its binding to the transmembrane receptor CD74. MIF also exhibits keto–enol tautomerase activity, believed to be vestigial in mammals. Starting from a 1μM hit from virtual screening, substituted benzoxazol-2-ones have been discovered as antagonists with IC 50 values as low as 7.5nM in a tautomerase...
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