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Highly sensitive and stable amperometric biosensors were developed for the determination of creatine and creatinine using creatine amidinohydrolase and sarcosine oxidase for creatine and creatinine amidohydrolase, creatine amidinohydrolase and sarcosine oxidase for creatinine, respectively. The enzymes were co-immobilized in a novel stabilizing poly(carbamoyl)sulfonate (PCS)-hydrogel matrix onto...
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