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The synthesis and in vitro anti human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activities of some unnatural β-l-nucleoside enantiomers related to the anti-HIV compound 2',3'-dideoxy-3'-fluoro-5-chlorouridine (β-d-3'Fdd5ClU) are reported. In contrast to β-d-3'Fdd5ClU, β-l-3'Fdd5ClU and the other l-congeners were devoid of significant anti-HIV effects, but β-l-2',3'-dideoxy-5-chlorocytidine...
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