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17α-Estradiol (17α-E2), the stereoisomer of 17β-estradiol (17β-E2), is considered a weak estrogen in mammals. However, little is known about its estrogenic potency in teleost fish, even though 17α-E2 has been frequently detected in aquatic environment. To investigate the estrogenic activity of 17α-E2, an in vitro assay based on the ligand-dependent interaction between medaka estrogen receptor alpha...
Although 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p -DDE), the major and most persistent metabolite of dichlorodiphenyltrichloroethane (DDT), was continually detected in wild fishes that showed abnormal gonad development such as intersex, little is known about the impact of p,p -DDE exposure on gonad development in fishes. To survey the effects of p,p -DDE on gonadal development and gene expressions,...
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