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The purpose of this study was to carry out an extensive examination of the C * concept for prediction of the topical antiviral efficacies of acyclovir (ACV) formulations in a hairless mouse model for the treatment of cutaneous herpes simplex virus type-1 (HSV-1) infections. This method is based on estimation of the free drug concentration at the target site (C * ), which is presumed...
For many years, our group has been working on the development of a novel approach for prediction of topical antiviral efficacies of acyclovir (ACV) formulations in the treatment of cutaneous HSV-1 infections in hairless mice. This approach is based on estimation of the free drug concentration (C * ), at the target site using the experimentally determined in vitro fluxes (J). First, a relationship...
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