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Cytochrome P450 (CYP) 2D6 activity is genetically determined, yielding extensive metabolizers (EMs) and poor metabolizers (PMs). Because of the involvement of this enzyme in the metabolism of many antipsychotic drugs, clinical implication of CYP2D6 genotyping has been expected for tailor-made antipsychotic drug therapy.Genotyping analysis showed that the mean steady-state plasma concentration (C ...
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