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Agomelatine, a novel melatonin analogue and anti-depressant that acts as an agonist on melatonin receptors 1 and 2 and as an antagonist at the 5HT2C receptor, was tested for its effects on cell proliferation in the dentate gyrus of the adult rat hippocampus under intact and flattened corticosterone rhythm conditions. Agomelatine stimulated mitosis rates in the intact male rat. Flattening the daily...
Fluoxetine stimulates proliferation of progenitor cells in the dentate gyrus of the adult hippocampus. There are suggestions that this action may underlie the therapeutic effects of such drugs in depression. Glucocorticoids also regulate neurogenesis, and there are multiple interactions between serotonin and corticoids. Diurnal cortisol rhythms are dysregulated in depression. We explored the role...
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