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Although colon cancers respond poorly to chemotherapeutic agents, 5-fluorouracil (5-FU) is considered the most effective single agent in the treatment of advanced colon cancer, whereas methotrexate has been reported as an ineffective agent. But both 5-FU and methotrexate inhibit de novo thymidylate synthesis. In the present study we assessed the sensitivity of folate-dependent thymidylate synthesis...
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