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Mammals dispose of cholesterol mainly through 7α-hydroxylated bile acids, and the enzyme catalyzing the 7α-hydroxylation, cholesterol 7α-hydroxylase (CYP7A1), has a deep impact on cholesterol homeostasis.In this review, we present the study of regulation of CYP7A1 as a good exemplification of the extraordinary contribution of molecular biology to the advancement of our understanding of metabolic pathways...
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