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Hypertension in pregnancy is a multifactorial disorder caused by a complex combination of environmental factors and several predisposing genes. Since estrogen modulates placental vascular development, estrogen synthases are considered plausible candidate genes. The aim of this haplotype-based case–control study was to estimate whether polymorphisms of the maternal estrogen synthesis genes (CYP19A1...
Calcitonin-related peptide α (CALCA) is a neuropeptide that is a very potent vasodilator. It has been reported that CALCA knockout mice have a significantly elevated systolic blood pressure (BP). The aims of this study were to discover novel polymorphisms or mutations in the 5′ flanking region of the human CALCA gene in Japanese subjects and to assess the association between this gene and essential...
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