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New 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives were prepared and tested in vitro as H 1 receptor antagonists. The compounds with 2-phenylamino substitution with meta-halide substituents at the phenyl ring, showed weak H 1 -antagonistic activity (pA 2 : 4.62-5.04) and this activity was completely lost in the case of meta-methyl...
New 2-(1-Piperazinyl)- and 2-(hexahydro-1H-1,4-diazepin-1-yl)benzothiazoles were prepared and tested as H 1 - and H 3 -receptor antagonists. A number of compounds showed weak H 1 -antagonistic activity, with pA 2 values ranging from 5.5 to 6.1. The simple alkyl substituted, 2-[1-(4-methyl and 4-ethyl)piperazinyl] analogues show increasing, moderate H 3 -antagonistic...
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