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Using the histamine H 3 receptor antagonist clobenpropit, the roles of histamine H 3 receptors in NMDA-induced necrosis were investigated in rat cultured cortical neurons. Clobenpropit reversed the neurotoxicity in a concentration-dependent manner, and showed peak protection at a concentration of 10 − 7 M. This protection was antagonized by the histamine H 3 receptor...
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