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Immunogenic cell death (ICD) can activate the body's immune system via dead cell antigens to achieve immunotherapy. Currently, small molecule drugs have been used for ICD treatment in clinical, however, how to precisely control the induced ICD while treating tumors is of great significance for improving therapeutic efficacy. Based on this, a sono/light dual response strategy to tumor therapy and activation...
Bismuth‐Based Semiconductors
Degradable bismuth semiconductor's properties are controlled by topological synthesis, which carries ivermectin under ultrasound and light action to produce reactive oxygen species (ROS) and heat, induce tumors to realize immunogenic cell death, and further activate T cells to achieve synergistic immunotherapy. More details can be found in article number 2304032 by Yuhao...
Solid tumors possess a unique internal environment with high‐level thiols (mainly glutathione), over‐expressed H2O2, and low oxygen partial pressure, which severely restrict the radiotherapy (RT) efficacy. To overcome the imperfections of RT alone, there is vital to design a multifunctional radiosensitizer that simultaneously achieves multimodal therapy and tumor microenvironment (TME) regulation...
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