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In recent studies, we analyzed effects of a large series of mAbs submitted to T-cell and adhesion structure sections of 6th International Workshop on Human Leukocyte Differentiation Antigens, on proliferative responses of a human CD4 + T cell clone. We found that certain mAbs to CD27, CD28, CD29, CD43 and CD44 markedly restore T cell responsiveness, only in the presence of the natural peptide...
T-cells that recognize mutated p21 Ras are relevant to immune surveillance systems against cancer. We report here evidence that immune responses of a T-cell clone recognizing mutated p21 Ras can be augmented by an analog peptide. Using spleen cells from a gastric cancer patient, we established the CD4 + αβ Th1-like clone C27 that recognizes wild-type ( 3 EYKLVVVGAGGVGKS 1 ...
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