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Cyclooxygenase (COX) is a well-known enzyme, which converts arachidonic acid to prostaglandins H2 (PGH2), which are the effective mediators of inflammation. 4′, 5 di-substituted 3-biphenyl acetic acids (BPA) and several α-methyl derivatives (MBPA) of it are widely used as powerful nonsteroidal anti-inflammatory and analgesic agents. We have chosen these activity data because the relation between the...
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