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Abrin-a is the most toxic fraction of lectins isolated from Abrus precatorius seeds and belongs to the family of type 2 ribosome inactivating proteins (RIP). This toxin may act as a defense molecule in plants against viruses, fungi and insects, where attachment of abrin-a to the exposed glycans on the surface of target cells is the crucial and initial step of its cytotoxicity. Although it has been...
Human blood group A, B, H, Ii, Le a and Le b antigens and their determinants expressed on ovarian cyst glycoproteins have been studied for over five decades. However, little is known about sialyl Le x and sialyl Le a glycotopes, which play essential roles in normal immunity, inflammation, and cancer cell metastasis. Furthermore, Le x and Le y were classified...
Previous reports on the carbohydrate specificities of Amaranthus caudatus lectin (ACL) and peanut agglutinin (PNA, Arachis hypogea) indicated that they share the same specificity for the Thomsen-Friedenreich (T α , Galβ1–3GalNAcα1–Ser/Thr) glycotope, but differ in monosaccharide binding – GalNAc≫Gal (inactive) for ACL; Gal≫GalNAc (weak) with respect to PNA. However, knowledge of the recognition...
Ricin (RCA 60 ) is a potent cytotoxic protein with lectin domains, contained in the seeds of the castor bean Ricinus communis. It is a potential biohazard. To corroborate the biological properties of ricin, it is essential to understand the recognition factors involved in the ricin–glycotope interaction. In previous reports, knowledge of the binding properties of ricin was limited to oligosugars...
In our recent publication, we defined core aspects of the carbohydrate specificity of domain-I of recombinant tandem-repeat-type galectin-4 from rat gastrointestinal tract (G4-N), especially its potent interaction with the linear tetrasaccharide Galβ1-3GlcNAcβ1-3Galβ1-4Glc (Iβ1-3L). The assumed role of galectin-4 as a microvillar raft stabilizer/organizer and as a malignancy-associated factor in hepatocellular...
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