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We established an anti-red blood cell (RBC) autoantibody transgenic mouse line, in which almost all B cells were deleted in the periphery. A small number of B-1 cells, however, escaped from deletion, survived and expanded in the peritoneal cavity and the gut, because of the absence of RBC. The activation of B-1 cells by enteric bacteria induced autoimmune hemolytic anemia (AIHA). In turn, AIHA was...
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