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Novel pyrazolo[1,5-a]pyridine derivatives were designed, synthesized and evaluated as orally active EP1 antagonists for the treatment of overactive bladder. Matched molecular pair analysis (MMPA) allowed the design of a new series of pyrazolo[1,5-a]pyridine derivatives 4–6. Structure-activity relationships (SAR) studies of 4–6 were performed, leading to identification of the nanomolar-level EP1 antagonist...
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