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Reticulons are a group of membrane‐bound proteins involved in diverse cellular functions, and are suggested to act as inhibitors of β‐secretase enzyme 1 (BACE1) activity that cleaves amyloid precursor protein. Reticulons are known to accumulate in the dystrophic neurites of Alzheimer's disease (AD), and studies have suggested that alterations in reticulons, such as increased aggregation, impair BACE1...
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