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The effect of lidocaine on the changes in tension and guanosine 3',5'-cyclic monophosphate (cGMP) content induced by atrial natriuretic peptide (ANP) and nitric oxide (NO) was examined in bovine tracheal smooth muscle preparations contracted with methacholine (0.3 μM). Lidocaine (10 μM) did not affect the methacholine-induced tensions, whereas 100 μM lidocaine significantly (P<0.01) attenuated...
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