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Background & Aims
Protein induced by vitamin K absence or antagonist‐II (PIVKA‐II) has been suggested as a serum biomarker for hepatocellular carcinoma (HCC) in Asian hepatitis B virus (HBV)‐treated subjects but no studies tested it in Caucasian cirrhotics long‐term nucleos(t)ide analogues (NUCs)‐treated. We assessed the detection accuracy of PIVKA‐II alone or in combination with alpha‐foetoprotein...
Purpose To evaluate the association of hepatitis B virus (HBV) genotypes, basal core promoter (BCP)/precore (PC) and S gene mutations with the clinical-epidemiological characteristics of acute hepatitis B (AHB) in Italy. Methods During July 2005–January 2007, 103 symptomatic AHB patients were enrolled and prospectively followed up at 15 national hospitals. HBV genotypes, BCP/PC and S gene...
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