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A new series of melatonin (MLT) dimers were obtained by linking together two melatonin units with a linear alkyl chain through the MLT acetamido group or through a C-2 carboxyalkyl function. The binding properties of these ligands were evaluated in in vivo experiments on cloned human MT 1 and MT 2 receptors expressed in NIH3T3 rat fibroblast cells. The class of 2-carboxyalkyl dimers...
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